Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability.

doi:10.1038/s41467-026-70655-1

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Article

Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability.

Nature communications - 30 Mar 2026

Gutierrez Catherine, Kwok Marwan, Ruthen Neil, Waddicor Peyton, Curran Christina, Ouspenskaia Tamara, Fu Doris, Smalec Brendan, Sedor Samantha, Knisbacher Binyamin A, Biran Anat, Nagler Adi, Garbicz Filip, Sewastianik Tomasz, Penailillo Johany, Lucas Fabienne, Yin Shanye, Liani Aviv, Chen Sarah, Lazarian Gregory, Witten Elizabeth, Dangle Nathan, Brunsting Ella L, Zheng Mei, Lin Emma S, Lee Madison J, Wells Blake, Pomerance Lucas, Hernández-Sánchez María, Li Shuqiang, Lin Ziao, Al'Khafaji Aziz, Wang Lili, Thakurela Sudhir, Livak Kenneth J, Neuberg Donna, Cymbalista Florence, Getz Gad, Regev Aviv, Churchman Stirling, Ten Hacken Elisa, Carrasco Ruben, Shao Sichen, Wu Catherine J

Abstract excerpt

Ribosomal protein mutations are increasingly associated with cancer risk and thought to perturb ribosome function. At the same time, they reportedly activate p53, a critical anti-cancer barrier. To determine how these mutations overcome this protective block to enable tumorigenesis, we generate an in vivo model of the hotspot ribosomal protein RPS15-S138F mutation identified as a putative driver of chronic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41912510
DOI: 10.1038/s41467-026-70655-1
PMCID: PMC13199580

Genes

RPS15
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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