Article
Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia.
Blood - 29 Nov 2018
Bretones Gabriel, Álvarez Miguel G, Arango Javier R, Rodríguez David, Nadeu Ferran, Prado Miguel A, Valdés-Mas Rafael, Puente Diana A, Paulo Joao A, Delgado Julio, Villamor Neus, López-Guillermo Armando, Finley Daniel J, Gygi Steven P, Campo Elías, Quesada Víctor, López-Otín Carlos
Abstract excerpt
Genomic studies have recently identified RPS15 as a new driver gene in aggressive and chemorefractory cases of chronic lymphocytic leukemia (CLL). RPS15 encodes a ribosomal protein whose conserved C-terminal domain extends into the decoding center of the ribosome. We demonstrate that mutations in highly conserved residues of this domain affect protein stability, by increasing its ubiquitin-mediated degradation,...
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