Article
RPS15 mutations rewire RNA translation in chronic lymphocytic leukemia.
Blood advances - 13 Jul 2021
Ntoufa Stavroula, Gerousi Marina, Laidou Stamatia, Psomopoulos Fotis, Tsiolas Georgios, Moysiadis Theodoros, Papakonstantinou Nikos, Mansouri Larry, Anagnostopoulos Achilles, Stavrogianni Niki, Pospisilova Sarka, Plevova Karla, Makris Antonios M, Rosenquist Richard, Stamatopoulos Kostas
Abstract excerpt
Recent studies of chronic lymphocytic leukemia (CLL) have reported recurrent mutations in the RPS15 gene, which encodes the ribosomal protein S15 (RPS15), a component of the 40S ribosomal subunit. Despite some evidence about the role of mutant RPS15 (mostly obtained from the analysis of cell lines), the precise impact of RPS15 mutations on the translational program in primary CLL cells remains largely unexplored....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.