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Magnesium isoglycyrrhizinate alleviates alcohol-associated liver disease through targeting HSD11B1

2025-10-03

Abstract excerpt

While magnesium isoglycyrrhizinate (MgIG) is a clinically approved therapy for alcohol-associated liver disease (ALD), its precise molecular targets and mechanisms remain uncharacterized. This study aimed to define MgIG’s hepatoprotective actions in chronic-binge ALD mouse models and ethanol/palmitic acid-exposed AML-12 hepatocytes. Through an integrated strategy encompassing RNA sequencing, molecular docking, and...

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Literature Corpus work
d099285b-abea-5eff-bd75-bcc572e5b815
DOI
10.1101/2025.10.02.679991
Open publication

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Magnesium isoglycyrrhizinate alleviates alcohol-associated liver disease through targeting HSD11B1DOI 10.1101/2025.10.02.679991
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