Article

Brain and Organoid Manifold Alignment (BOMA), a machine learning framework for comparative gene expression analysis across brains and organoids

2022-06-14

Abstract excerpt

Organoids have become valuable models for understanding cellular and molecular mechanisms in human development including brains. However, whether developmental gene expression programs are preserved between human organoids and brains, especially in specific cell types, remains unclear. Importantly, there is a lack of effective computational approaches for comparative data analyses between organoids and developing...

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Literature Corpus work: d076861b-91b8-58c3-8ef7-85995df770b2
DOI: 10.1101/2022.06.13.495946

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