Article

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

2024-08-31

Abstract excerpt

Missense mutations in the amyloid precursor protein (APP) and presenilin-1 (PSEN1) cause early-onset familial Alzheimer’s disease (FAD) and alter proteolytic production of secreted 38-to-43-residue amyloid β-peptides (Aβ) by the PSEN1-containing γ-secretase complex, ostensibly supporting the amyloid hypothesis of pathogenesis. However, proteolysis of APP substrate by γ-secretase is processive, involving initial en...

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Literature Corpus work: d02cc211-e506-5552-95bb-539df6335f7b
DOI: 10.1101/2024.08.30.610520

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