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Article

Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes.

Cell reports - 27 Feb 2024

Devkota Sujan, Zhou Rui, Nagarajan Vaishnavi, Maesako Masato, Do Hung, Noorani Arshad, Overmeyer Caitlin, Bhattarai Sanjay, Douglas Justin T, Saraf Anita, Miao Yinglong, Ackley Brian D, Shi Yigong, Wolfe Michael S

Abstract excerpt

Mutations that cause familial Alzheimer's disease (FAD) are found in amyloid precursor protein (APP) and presenilin, the catalytic component of γ-secretase, that together produce amyloid β-peptide (Aβ). Nevertheless, whether Aβ is the primary disease driver remains controversial. We report here that FAD mutations disrupt initial proteolytic events in the multistep processing of APP substrate C99 by γ-secretase....

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Identifiers

PMID: 38349793
DOI: 10.1016/j.celrep.2024.113761
PMCID: PMC10941010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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