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Article

Evidence For and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 4 Apr 2016

Jayne Tanya, Newman Morgan, Verdile Giuseppe, Sutherland Greg, Münch Gerald, Musgrave Ian, Moussavi Nik Seyyed Hani, Lardelli Michael

Abstract excerpt

The majority of mutations causing familial Alzheimer's disease (fAD) have been found in the gene PRESENILIN1 (PSEN1) with additional mutations in the related gene PRESENILIN2 (PSEN2). The best characterized function of PRESENILIN (PSEN) proteins is in γ-secretase enzyme activity. One substrate of γ-secretase is encoded by the gene AMYLOID BETA A4 PRECURSOR PROTEIN (AβPP/APP) that is a fAD mutation locus. AβPP is...

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Source

Identifiers

PMID: 27060961
DOI: 10.3233/JAD-151186

Genes

PSEN1
PSEN2
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence For and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease.PMID 27060961Read ↗

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