Article

Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes

2023-09-09

Abstract excerpt

Alzheimer’s disease is characterized pathologically by cerebral deposition of 42-residue amyloid β-peptide (Aβ42), proteolytically produced from amyloid precursor protein (APP) by β- and γ-secretases. 1 Although mutations in APP and presenilin, the catalytic component of γ-secretase, cause familial Alzheimer’s disease (FAD), a role for Aβ42 as the primary disease driver has not been clearly established and remain...

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Literature Corpus work: 7beab4b8-5005-5ee4-83c6-21f3afa5d4c9
DOI: 10.1101/2023.09.08.556905

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