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Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging

2023-05-14

Abstract excerpt

Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. The conferment of beneficial-pluripotency related traits via in vivo partial cellular reprogramming (IVPR) significantly extends lifespan and restores aging phenotypes in mouse models....

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Identifiers and source

Literature Corpus work
393f0836-52b9-54d1-b6b1-8aabfe239b3c
DOI
10.1101/2023.05.12.540500
Open publication

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Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature agingDOI 10.1101/2023.05.12.540500
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