Article

Plasma glucosylceramide levels are regulated by<i>ATP10D</i>and are not involved in Parkinson’s disease pathogenesis

2024-09-14

Abstract excerpt

GBA1 variants and decreased glucocerebrosidase (GCase) activity are implicated in Parkinson’s disease (PD). We investigated the hypothesis that increased levels of glucosylceramide (GlcCer), one of GCase main substrates, are involved in PD pathogenesis. Using multiple genetic methods, we show that ATP10D , not GBA1 , is the main regulator of plasma GlcCer levels, yet it is not involved in PD pathogenesis. Plasma G...

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Literature Corpus work: 141e07b2-3609-5d5f-86b1-9a676c9ffa50
DOI: 10.1101/2024.09.13.24313644

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