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Article

Activating PIK3CA alleles and lymphangiogenic phenotype of lymphatic endothelial cells isolated from lymphatic malformations.

Human molecular genetics - 15 Feb 2015

Osborn Alexander J, Dickie Peter, Neilson Derek E, Glaser Kathryn, Lynch Kaari A, Gupta Anita, Dickie Belinda Hsi

Abstract excerpt

Lymphatic malformations (LMs) are developmental anomalies of the lymphatic system associated with the dysmorphogenesis of vascular channels lined by lymphatic endothelial cells (LECs). Seeking to identify intrinsic defects in affected LECs, cells were isolated from malformation tissue or fluid on the basis of CD31 and podoplanin (PDPN) expression. LECs from five unrelated LM lesions were characterized, including...

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Share to Class I Phosphatidylinositol 3-Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25292196
DOI: 10.1093/hmg/ddu505

Genes

CXCR4
PDPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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