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Article

Interhelical loops within the bHLH domain are determinant in maintaining TWIST1-DNA complexes.

Journal of biomolecular structure & dynamics - 1 Jan 2014

Bouard Charlotte, Terreux Raphael, Hope Jennifer, Chemelle Julie Anne, Puisieux Alain, Ansieau Stéphane, Payen Léa

Abstract excerpt

The basic helix-loop-helix (bHLH) transcription factor TWIST1 is essential to embryonic development, and hijacking of its function contributes to the development of numerous cancer types. It forms either a homodimer or a heterodimeric complex with an E2A or HAND partner. These functionally distinct complexes display sometimes antagonistic functions during development, so that alterations in the balance between...

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Share to Acrocephalosyndactylia
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23527594
DOI: 10.1080/07391102.2012.762722
PMCID: PMC3869052

Genes

TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interhelical loops within the bHLH domain are determinant in maintaining TWIST1-DNA complexes.PMID 23527594Read ↗

Computational modeling of the bHLH domain of the transcription factor TWIST1 and R118C, S144R and K145E mutants.Semantic proximity Read ↗

TWIST1 homodimers and heterodimers orchestrate lineage-specific differentiationSemantic proximity Read ↗

TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation.Semantic proximity Read ↗

An ENU-induced mutation in Twist1 transactivation domain causes hindlimb polydactyly with complete penetrance and dominant-negatively impairs E2A-dependent transcription.Semantic proximity Read ↗

Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities.Semantic proximity Read ↗

Discovery of a hidden transient state in all bromodomain familiesSemantic proximity Read ↗

Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosisSemantic proximity Read ↗

A bHLH code for cardiac morphogenesis.Semantic proximity Read ↗

Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities.Semantic proximity Read ↗

Homologous BHLH transcription factors induce distinct deformations of torsionally-stressed DNA: a potential transcription regulation mechanismSemantic proximity Read ↗

Phosphoregulation of Twist1 provides a mechanism of cell fate control.Semantic proximity Read ↗

Mutations in the basic domain and the loop-helix II junction of TWIST abolish DNA binding in Saethre-Chotzen syndrome.Semantic proximity Read ↗

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