Article

Small extracellular vesicles reflect senescence progression in human bone marrow–derived mesenchymal stem cells during hollow fiber bioreactor culture

2025-12-31

Abstract excerpt

Prolonged three-dimensional culture exposes stem cells to sustained microenvironmental and mechanical stresses that can promote aging- and senescence-associated phenotypic alterations. This study examined how long-term expansion of human bone marrow–derived mesenchymal stem cells (BMSCs) in a hollow fiber bioreactor (HFB) influences cellular senescence and the molecular composition of secreted small extracellular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cfabb837-a0b5-58e6-92ef-66056114a2ed
DOI: 10.64898/2025.12.31.697149

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Small extracellular vesicles reflect senescence progression in human bone marrow–derived mesenchymal stem cells during hollow fiber bioreactor cultureDOI 10.64898/2025.12.31.697149Read

Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamicsSemantic proximity Read

Extracellular Vesicles from Senescent Stem Cells: A Converging Nexus Between Aging, Regeneration, and CancerSemantic proximity Read

Engineering Mesenchymal Stem Cells to Extend Healthspan: Therapeutic Potential, Challenges, and Future SolutionsSemantic proximity Read

Human ESC‐sEVs alleviate age‐related bone loss by rejuvenating senescent bone marrow‐derived mesenchymal stem cellsSemantic proximity Read

Red blood Cell-derived Extracellular Vesicles as biomaterials: the opportunity of freezing-induced accelerated agingSemantic proximity Read

Small extracellular vesicles produced by homeostatic phenotype BMSC promote bone regeneration by transferring anti-senescent factor JMJD6.Semantic proximity Read

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of agingSemantic proximity Read

Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to LightSemantic proximity Read

Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responsesSemantic proximity Read

Proteomic Profiling of Mesenchymal Stem Cell-Derived Extracellular Vesicles: Impact of Isolation Methods on Protein CargoSemantic proximity Read

Mesenchymal stem cells lose the senescent phenotype under 3D cultivation.Semantic proximity Read

Effect of aging on behaviour of mesenchymal stem cellsSemantic proximity Read