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Article

Small extracellular vesicles produced by homeostatic phenotype BMSC promote bone regeneration by transferring anti-senescent factor JMJD6.

Journal of nanobiotechnology - 21 Feb 2026

Fu Songning, Liu Lu, Xu Feng, Cheng Jin, Liu Yadong, Liu Tianyu, Fu Changfeng, Wu Yanhua, Zhou Nan, Yang Qiwei, Wang Yuanyi

Abstract excerpt

The therapeutic efficacy of extracellular vesicles (EVs) depends on the status of their donor cells. Cellular senescence of bone marrow mesenchymal stem cells (BMSCs), which induces significant changes to cellular secretome, greatly affects the osteogenesis of the donor BMSCs along with BMSC-derived EVs. Stem cells prefer a homeostatic self-renewing state to alleviate the senescence and loss of stemness caused by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Jumonji Domain-Containing Histone Demethylases

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Source

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Identifiers

PMID: 41723429
DOI: 10.1186/s12951-026-04199-3
PMCID: PMC13032466

Genes

JMJD6
CYP19A1
LAMA1
LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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