Article

The FDA-approved drug nitazoxanide is a potent inhibitor of human seasonal coronaviruses acting at postentry level: effect on the viral spike glycoprotein

2022-07-13

Abstract excerpt

Coronaviridae is recognized as one of the most rapidly evolving virus family as a consequence of the high genomic nucleotide substitution rates and recombination. The family comprises a large number of enveloped, positive-sense single-stranded RNA viruses, causing an array of diseases of varying severity in animals and humans. To date, seven human coronaviruses (HCoV) have been identified, namely HCoV-229E, HCoV-N...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf9f3afa-42d8-570d-afba-8293aa504274
DOI: 10.1101/2022.07.13.499346

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The FDA-approved drug nitazoxanide is a potent inhibitor of human seasonal coronaviruses acting at postentry level: effect on the viral spike glycoproteinDOI 10.1101/2022.07.13.499346Read

The FDA-approved drug nitazoxanide is a potent inhibitor of human seasonal coronaviruses acting at postentry level: effect on the viral spike glycoproteinSemantic proximity Read

The recent outbreaks of human coronaviruses: A medicinal chemistry perspectiveSemantic proximity Read

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamstersSemantic proximity Read

In Vitro Inhibition of SARS-CoV-2 Infection by Bromhexine hydrochlorideSemantic proximity Read

Coronavirus (2019-nCoV) Deactivation via Spike Glycoprotein Shielding by Old Drugs, Bioinformatic StudySemantic proximity Read

Viral polymerase binding and broad-spectrum antiviral activity of molnupiravir against human seasonal coronavirusesSemantic proximity Read

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike proteinSemantic proximity Read

Seasonal Human Coronaviruses OC43, 229E, and NL63 Induce Cell Surface Modulation of Entry Receptors and Display Host Cell-Specific Viral Replication KineticsSemantic proximity Read

Seasonal human coronaviruses OC43, 229E, and NL63 induce cell surface modulation of entry receptors and display host cell-specific viral replication kineticsSemantic proximity Read

Methylene Blue Is a Nonspecific Protein-Protein Interaction Inhibitor with Potential for Repurposing as an Antiviral for COVID-19Semantic proximity Read

Astrovirus Replication Is Inhibited by Nitazoxanide In Vitro and In VivoSemantic proximity Read

Repurposing Cilnidipine as an Entry Inhibitor Against Crimean–Congo Haemorrhagic Fever Pseudovirus InfectionSemantic proximity Read