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Viral polymerase binding and broad-spectrum antiviral activity of molnupiravir against human seasonal coronaviruses

4 Oct 2021

Abstract excerpt

Endemic seasonal coronaviruses cause morbidity and mortality in a subset of patients, but no specific treatment is available. Molnupiravir is a promising pipeline antiviral drug for treating SARS-CoV-2 infection potentially by targeting RNA-dependent RNA polymerase (RdRp). This study aims to evaluate the potential of repurposing molnupiravir for treating seasonal human coronavirus (HCoV) infections. Molecular...

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PMID: 34619630
DOI: 10.1016/j.virol.2021.09.009

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