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Article

Protective phenotypes of club cells and alveolar macrophages are favored as part of endotoxin-mediated prevention of asthma.

Experimental biology and medicine (Maywood, N.J.) - 1 Jul 2015

García Luciana N, Leimgruber Carolina, Uribe Echevarría Elisa M, Acosta Patricio L, Brahamian Jorge M, Polack Fernando P, Miró María S, Quintar Amado A, Sotomayor Claudia E, Maldonado Cristina A

Abstract excerpt

Atopic asthma is a chronic allergic disease that involves T-helper type 2 (Th2)-inflammation and airway remodeling. Bronchiolar club cells (CC) and alveolar macrophages (AM) are sentinel cells of airway barrier against inhaled injuries, where allergy induces mucous metaplasia of CC and the alternative activation of AM, which compromise host defense mechanisms and amplify Th2-inflammation. As there is evidence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25504013
DOI: 10.1177/1535370214562338
PMCID: PMC4935407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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