Article
Genetic polymorphism of transforming growth factor β1 and tumor necrosis factor α is associated with asthma and modulates the severity of asthma.
Respiratory care - 1 Aug 2013
Chiang Chi-Huei, Chuang Chiao-Hui, Liu Shiou-Ling, Shen Horng-Der
Abstract excerpt
BACKGROUND: The role of transforming growth factor β1 (TGF-β1) and tumor necrosis factor α (TNF-α) in asthma is unclear. The aim of this study was to assess the relationships among polymorphisms, clinical phenotypes, and the serum levels of TGF-β1 and TNF-α. METHODS: Polymorphisms of promoter of TGF-β1 (C-509T locus) and TNF-α (G-308 A locus; rs 1800629) in 217 asthmatic patients and 110 healthy controls were...
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