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Article

The landscape of cancer rewired GPCR signaling axes

2023-03-14

Abstract excerpt

We explored the dysregulation of GPCR ligand signaling systems in cancer transcriptomics datasets to uncover new therapeutics opportunities in oncology. We derived an interaction network of receptors with ligands and their biosynthetic enzymes, which revealed that multiple GPCRs are differentially regulated together with their upstream partners across cancer subtypes. We showed that biosynthetic pathway enrichment...

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Identifiers and source

Literature Corpus work
cf64bbfe-45b3-5a77-afd2-e67544c2a6bf
DOI
10.1101/2023.03.13.532291
Open publication

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The landscape of cancer rewired GPCR signaling axesDOI 10.1101/2023.03.13.532291
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