Article

piTracer - Automatic reconstruction of molecular cascades for the identification of synergistic drug targets

2023-04-09

Abstract excerpt

Cancer cells frequently undergo metabolic reprogramming as a mechanism of resistance against chemotherapeutic drugs. Metabolomic profiling provides a direct readout of metabolic changes and can thus be used to identify these tumor escape mechanisms. Here, we introduce piTracer, a computational tool that uses multi-scale molecular networks to identify potential combination therapies from pre- and post-treatment met...

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Literature Corpus work: ab6e6070-5158-54e5-8620-2479e4cd55ae
DOI: 10.1101/2023.04.08.535933

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