Article

Dysregulated synaptic gene expression in oligodendrocytes of spinal and bulbar muscular atrophy

2024-01-12

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by an expanded CAG repeat in the androgen receptor ( AR ) gene. To elucidate the cell type-specific temporal gene expression in SBMA, we performed single-nucleus RNA sequencing on the spinal cords of AR-97Q mice. Among all cell types, oligodendrocytes (OLs) had the highest number of differentially expressed genes before disease onset. An...

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Literature Corpus work: 1c0d78e9-e7ca-5868-8b27-7841a32ceeb2
DOI: 10.1101/2024.01.11.575248

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