Article

Conserved Aberrant Developmental Trajectories of Human and Mouse SBMA Motor Neurons

2025-09-17

Abstract excerpt

Spinal bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by a polyglutamine repeat expansion in the androgen receptor gene (AR). Lower motor neuron loss is a key feature of the disease, yet it remains poorly understood why these cells are affected. The transcriptional mechanisms underlying SBMA pathogenesis and how these evolve across developmental and disease stages remains incompletely defined. To...

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Literature Corpus work: 04fe3936-1560-5ce4-b32a-9383f14b0759
DOI: 10.1101/2025.09.17.674754

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