Article

Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs

2020-01-28

Abstract excerpt

<title>Abstract</title> <p>Spinal bulbar muscular atrophy (SBMA) is an adult-onset, slowly progressive motor neuron disease caused by abnormal CAG repeat expansion in the androgen receptor (AR) gene. Although ligand (testosterone)-dependent mutant AR aggregation has been shown to play important roles in motor neuronal degeneration by the analyses of transgenic mice models and in vitro cell culture models, the und...

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Literature Corpus work: e7497876-4da5-51fe-9466-89ecd472d8bc
DOI: 10.21203/rs.2.20096/v2

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