Article
Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals.
Annals of the New York Academy of Sciences - 1 Apr 2013
Nokoff Natalie, Rewers Marian
Abstract excerpt
Type 1 diabetes (T1D) is an autoimmune disease characterized by known genetic risk factors with T cell-mediated infiltration and destruction of the beta cells within pancreatic islets. Autoantibodies are the most significant preclinical marker of T1D, and birth cohort studies have provided important insights into the natural history of autoimmunity and T1D. While HLA remains the strongest genetic risk factor, a...
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