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Article

Ufl1 deficiency causes kidney atrophy associated with disruption of endoplasmic reticulum homeostasis.

Journal of genetics and genomics = Yi chuan xue bao - 20 May 2021

Zhou You, Ye Xifu, Zhang Chenlu, Wang Jiabao, Guan Zeyuan, Yan Juzhen, Xu Lu, Wang Ke, Guan Di, Liang Qian, Mao Jian, Zhou Junzhi, Zhang Qian, Wu Xiaoying, Wang Miao, Cong Yu-Sheng, Liu Jiang

Abstract excerpt

The UFMylation modification is a novel ubiquitin-like conjugation system, consisting of UBA5 (E1), UFC1 (E2), UFL1 (E3), and the conjugating molecule UFM1. Deficiency in this modification leads to embryonic lethality in mice and diseases in humans. However, the function of UFL1 is poorly characterized. Studies on Ufl1 conditional knockout mice have demonstrated that the deletion of Ufl1 in cardiomyocytes and in...

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Identifiers

PMID: 34148841
DOI: 10.1016/j.jgg.2021.04.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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