Article

GraphTME: a framework for predicting response to immune checkpoint inhibitors by interpreting cell-cell interactions in the tumour microenvironment using spatial transcriptomics of tumour tissue

2025-07-26

Abstract excerpt

Immune checkpoint inhibitors (ICIs) have been used to treat cancer by reactivating T-cell responses against tumours, yet clinical efficacy remains limited due to low response rates and the lack of robust predictive biomarkers. The tumour microenvironment critically shapes ICI responsiveness by modulating antitumour immunity, necessitating a deeper understanding of spatially organised cell–cell interactions. Imagin...

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Literature Corpus work: cf3d4292-22e5-549d-8f68-4e766adef43b
DOI: 10.1101/2025.07.24.665835

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