Article

NEST: Spatially-mapped cell-cell communication patterns using a deep learning-based attention mechanism

2024-03-22

Abstract excerpt

Dysregulation of communication between cells mediates complex diseases such as cancer and diabetes. However, detecting cell-cell communication (CCC) at scale remains one of the greatest challenges in transcriptomics. While gene expression measured with single-cell RNA sequencing and spatial transcriptomics reinvigorated computational approaches to detecting CCC, most existing methods exhibit high false positive ra...

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Literature Corpus work: 4aeae4c8-631b-5c7f-b15b-886bb828715d
DOI: 10.1101/2024.03.19.585796

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