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Intratracheal trimerized nanobody cocktail protects against SARS-CoV-2 Omicron in mice

2022-04-22

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 Omicron variants are highly resistant to vaccine-induced immunity and human monoclonal antibodies. Here, we demonstrate that a novel nanobody TP86 potently neutralized both BA.1 and BA.2 Omicron variants, and that the TP17 and TP86 nanobody cocktail broadly neutralized in vitro all VOCs as well as D614G. Furthermore, this cocktail showed therapeutic efficacy in vivo on VOCs u...

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Identifiers and source

Literature Corpus work
cf23d7c4-6407-50c1-b693-2d7caced6ee7
DOI
10.21203/rs.3.rs-1579128/v1
Open publication

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Intratracheal trimerized nanobody cocktail protects against SARS-CoV-2 Omicron in miceDOI 10.21203/rs.3.rs-1579128/v1
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