Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current.

Abstract excerpt

Hundreds of mutations in the SCN1A sodium channel gene confer a wide spectrum of epileptic disorders, requiring efficient model systems to study cellular mechanisms and identify potential therapeutic targets. We recently demonstrated that Drosophila knock-in flies carrying the K1270T SCN1A mutation known to cause a form of genetic epilepsy with febrile seizures plus (GEFS+) exhibit a heat-induced increase in...

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• Action Potentials
• Drosophila
• Epilepsies, Myoclonic
• GABAergic Neurons
• Interneurons