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Article

Moderate Increase of Indoxyl Sulfate Promotes Monocyte Transition into Profibrotic Macrophages.

PloS one - 1 Jan 2016

Barisione Chiara, Garibaldi Silvano, Furfaro Anna Lisa, Nitti Mariapaola, Palmieri Daniela, Passalacqua Mario, Garuti Anna, Verzola Daniela, Parodi Alessia, Ameri Pietro, Altieri Paola, Fabbi Patrizia, Ferrar Pier Francesco, Brunelli Claudio, Arsenescu Violeta, Balbi Manrico, Palombo Domenico, Ghigliotti Giorgio

Abstract excerpt

OBJECTIVE: The uremic toxin Indoxyl-3-sulphate (IS), a ligand of Aryl hydrocarbon Receptor (AhR), raises in blood during early renal dysfunction as a consequence of tubular damage, which may be present even when eGFR is normal or only moderately reduced, and promotes cardiovascular damage and monocyte-macrophage activation. We previously found that patients with abdominal aortic aneurysms (AAAs) have higher...

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Share to Antigens, Differentiation, Myelomonocytic
Share to Aortic Aneurysm, Abdominal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD163 Antigen

Share to Cell Transdifferentiation

Share to Chemotaxis, Leukocyte

Share to Glomerular Filtration Rate

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Share to Receptors, Aryl Hydrocarbon

Source

Open in PubMed Open full text

Identifiers

PMID: 26925780
DOI: 10.1371/journal.pone.0149276
PMCID: PMC4771744

Genes

CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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