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A trove of antiviral TRIM family E3 ligases in reptiles

2025-06-25

Abstract excerpt

Scaled reptiles (squamates) naturally encounter orthoflaviviruses and in some cases robustly resist infection. To identify antiviral defenses encoded in reptile genomes, we screened a green iguana cDNA library and discovered a reptilian TRIM-family E3 ubiquitin ligase that reduces dengue virus replication ∼10,000-fold in human cells. Experimental evolution identified orthoflavivirus capsid as a key determinant of...

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Identifiers and source

Literature Corpus work
cec47bb7-3250-5777-8bef-e71f4d3acb01
DOI
10.1101/2025.06.23.661133
Open publication

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A trove of antiviral TRIM family E3 ligases in reptilesDOI 10.1101/2025.06.23.661133
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