Article

Human TMPRSS2 non-catalytic ectodomain and SARS-CoV-2 S2’ subunit interaction mediated SARS-CoV-2 endocytosis: A model proposal with virtual screening for potential drug molecules to inhibit this interaction

2022-04-14

Abstract excerpt

<title>Abstract</title> <p>This study proposes a novel model for SARS-CoV-2 viral integration into the host cell via endocytosis pathway and hence a target for preventive treatment of COVID-19 infection. SARS-CoV-2 spike protein undergoes proteolytic cleavage at S1-S2 cleavage site and the cleaved out S2 domain is further cleaved by the activated serine protease domain of humanTMPRSS2 to become S2'. The activated...

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Literature Corpus work: cec1335f-5d8d-5b27-ab17-47fb9e9eb49f
DOI: 10.21203/rs.3.rs-1552691/v1

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Human TMPRSS2 non-catalytic ectodomain and SARS-CoV-2 S2’ subunit interaction mediated SARS-CoV-2 endocytosis: A model proposal with virtual screening for potential drug molecules to inhibit this interactionDOI 10.21203/rs.3.rs-1552691/v1Read

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