Article

Structural Insights Into the Design of Peptide-based Drug or Diagnostic Reagent Antagonizing SARS-COV-2

2020-08-19

Abstract excerpt

<title>Abstract</title> <p>Background Very limited drug and diagnostic reagents are currently available to tackle the emergence of SARS-CoV-2. However, recent findings about the structure of the complex about PD of ACE2 and RBD of SARS-CoV-2 spike protein hold great promise for the design of novel vaccines and peptides. To provide some suggestions for the design of peptide-based drug or diagnostic reagents antag...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6ec0be1-c0f6-5bb4-b358-36074fbaeb82
DOI: 10.21203/rs.3.rs-45305/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural Insights Into the Design of Peptide-based Drug or Diagnostic Reagent Antagonizing SARS-COV-2DOI 10.21203/rs.3.rs-45305/v1Read

Antiviral Peptides as Promising Therapeutics against SARS-CoV-2Semantic proximity Read

Structural perspective of the interactions of ACE2 and SARS CoV-2 Spike protein RBDSemantic proximity Read

Inhibition of SARS-CoV-2 pathogenesis by potent peptides designed by the mutation of ACE2 binding region.Semantic proximity Read

Computational study of the strong binding mechanism of SARS-CoV-2 spike and ACE2Semantic proximity Read

A novel peptide analogue of spike glycoprotein shows antiviral properties against SARS-CoV-2: An in silico approach through molecular docking, molecular dynamics simulation and MM-PB/GBSA calculationsSemantic proximity Read

The Distal Polybasic Cleavage Sites of SARS-CoV-2 Spike Protein Enhance Spike Protein-ACE2 BindingSemantic proximity Read

Peptide Scanning of SARS-CoV and SARS-CoV-2 Spike Protein Subunit 1 Reveals Potential Additional Receptor Binding SitesSemantic proximity Read

Peptide Antidotes to SARS-CoV-2 (COVID-19)Semantic proximity Read

Altered interaction between RBD and ACE2 receptor contributes towards the increased transmissibility of SARS CoV-2 delta, kappa, beta, and gamma strains with RBD double mutationsSemantic proximity Read

Computational and Experimental Identification of Potential Neutralizing Peptides Derived from Human ACE2 Against SARS-CoV-2 InfectionSemantic proximity Read

A comprehensive examination of ACE-2 receptor and prediction of spike glycoprotein and ACE-2 interaction based on in silico analysis of ACE-2 receptorSemantic proximity Read

Enhanced Binding of SARS-CoV-2 Spike Protein to Receptor by Distal Polybasic Cleavage Sites.Semantic proximity Read