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Drug Repurposing for Covid-19: Discovery of Potential Small-Molecule Inhibitors of Spike Protein-ACE2 Receptor Interaction Through Virtual Screening and Consensus Scoring

2020-06-17

Abstract excerpt

<h4>Objective: </h4> There is an increased interest in drug repurposing against Covid-19 (SARS-CoV-2) as its spread has significantly outpaced development of effective therapeutics. Our aim is to identify approved drugs that can inhibit the interaction of SARS-CoV-2 spike protein with human angiotensin-converting enzyme 2 (ACE2) that is critical for coronavirus infection. <h4>Methods: </h4> The published crystal s...

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Literature Corpus work
79c5dca6-51f2-592a-acdd-3bb9b33df1af
DOI
10.26434/chemrxiv.12482435.v1
Open publication

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