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Article

Loss of the Drosophila m-AAA mitochondrial protease paraplegin results in mitochondrial dysfunction, shortened lifespan, and neuronal and muscular degeneration.

Cell death & disease - 21 Feb 2018

Pareek Gautam, Thomas Ruth E, Pallanck Leo J

Abstract excerpt

The progressive accumulation of dysfunctional mitochondria is implicated in aging and in common diseases of the elderly. To oppose this occurrence, organisms employ a variety of strategies, including the selective degradation of oxidatively damaged and misfolded mitochondrial proteins. Genetic studies in yeast indicate that the ATPase Associated with diverse cellular Activities (AAA+) family of mitochondrial...

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PMID: 29467464
DOI: 10.1038/s41419-018-0365-8
PMCID: PMC5833341

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SPG7

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