Article

Repurposed Drugs Block Toxin-Driven Platelet Clearance by the Hepatic Ashwell-Morell Receptor to Clear <i>Staphylococcus aureus</i> Bacteremia

2020-07-07

Abstract excerpt

<h4>ABSTRACT</h4> Staphylococcus aureus (SA) bloodstream infections cause high morbidity and mortality (20-30%) despite modern supportive care. In a human bacteremia cohort, development of thrombocytopenia was correlated to increased mortality and increased α-toxin expression by the pathogen. Platelet-derived antibacterial peptides are important in bloodstream defense against SA, but α-toxin decreased platelet vi...

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Literature Corpus work: ce7b65c8-f977-571e-89df-2206ebfa0a77
DOI: 10.1101/2020.07.06.190322

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