Article

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

2023-07-19

Abstract excerpt

Major histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, has until recently been reported to be monomorphic. Tumor cell-specific MR1 restricted T cell receptors (TCRs) have been described, offering potential therapeutic application for cancer treatment. We show that human T cells expressing a TCR derived from an MR1-restricted T cell clone, termed MC.7.G5 (7G5.T...

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Literature Corpus work: ce608101-68e3-57c5-a93e-70c2e1118abb
DOI: 10.1101/2023.07.17.548997

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