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Investigation of heterochromatin protein 1 function in the malaria parasite <i>Plasmodium falciparum</i> using a conditional domain deletion and swapping approach

2020-11-26

Abstract excerpt

The human malaria parasite Plasmodium falciparum encodes a single ortholog of heterochromatin protein 1 (PfHP1) that plays a crucial role in the epigenetic regulation of various survival-related processes. PfHP1 is essential for parasite proliferation and the heritable silencing of genes linked to antigenic variation, host cell invasion and sexual conversion. Here, we employed CRISPR/Cas9-mediated genome editing...

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Literature Corpus work
ce2000a0-de78-5e9e-8fba-ebb62f74b61c
DOI
10.1101/2020.11.26.400325
Open publication

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Investigation of heterochromatin protein 1 function in the malaria parasite <i>Plasmodium falciparum</i> using a conditional domain deletion and swapping approachDOI 10.1101/2020.11.26.400325
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