Article

Jumonji-C domain containing demethylase 1 is critical for heterochromatin organization in <i>Plasmodium falciparum</i>

2025-10-08

Abstract excerpt

Despite the central importance of epigenetic regulation in enabling adaptation and pathogenicity of malaria parasites, mechanisms controlling heterochromatin distribution in Plasmodium falciparum are poorly understood. Here, we identified P. falciparum Jumonji C domain-containing histone demethylase 1, PfJmjC1, as a key regulator of heterochromatin. Parasites lacking PfJmjC1 are viable in vitro but display slig...

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Literature Corpus work: a2510e1c-666e-5908-a4dc-291a67f29ae6
DOI: 10.1101/2025.10.08.680194

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