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Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites

1 Mar 2018

Abstract excerpt

Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during blood infection in humans. By assessing genome-wide heterochromatin protein 1 (HP1) occupancy, we present a comprehensive analysis of heterochromatin landscapes across different Plasmodium species, strains, and life cycle stages. Common...

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Invertebrate Immune Response Mechanisms
Malaria Research and Control
vaccines and immunoinformatics approaches

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29503181
DOI: 10.1016/j.chom.2018.01.008

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