Article
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.
Nature communications - 2 Nov 2021
Li Tingting, Han Xiaojian, Gu Chenjian, Guo Hangtian, Zhang Huajun, Wang Yingming, Hu Chao, Wang Kai, Liu Fengjiang, Luo Feiyang, Zhang Yanan, Hu Jie, Wang Wang, Li Shenglong, Hao Yanan, Shen Meiying, Huang Jingjing, Long Yingyi, Song Shuyi, Wu Ruixin, Mu Song, Chen Qian, Gao Fengxia, Wang Jianwei, Long Shunhua, Li Luo, Wu Yang, Gao Yan, Xu Wei, Cai Xia, Qu Di, Zhang Zherui, Zhang Hongqing, Li Na, Gao Qingzhu, Zhang Guiji, He Changlong, Wang Wei, Ji Xiaoyun, Tang Ni, Yuan Zhenghong, Xie Youhua, Yang Haitao, Zhang Bo, Huang Ailong, Jin Aishun
Abstract excerpt
Accumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, 3 receptor binding domain (RBD) specific monoclonal antibodies (mAbs), 58G6, 510A5 and 13G9, with high neutralizing potency blocking authentic SARS-CoV-2 virus display remarkable efficacy against authentic B.1.351 virus....
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