Article

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

2022-06-26

Abstract excerpt

SARS-CoV-2 Omicron variants have generated a world-wide health crisis due to resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of antibodies induced by vaccination. Here, we describe the SARS-CoV-2 neutralizing SP1-77 antibody that was generated from a humanized mouse model with a single human V H 1-2 and Vκ1-33-associated with immensely diverse complementarity-determining-region-3 (CDR3)...

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Identifiers and source

Literature Corpus work: 78720133-1a38-5a00-b2b0-1349c548c35d
DOI: 10.1101/2022.06.26.497634

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