Article
Antibody drugs targeting SARS-CoV-2: Time for a rethink?
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jul 2024
Liang Likeng, Wang Bo, Zhang Qing, Zhang Shiwu, Zhang Sihe
Abstract excerpt
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) heavily burdens human health. Multiple neutralizing antibodies (nAbs) have been issued for emergency use or tested for treating infected patients in the clinic. However, SARS-CoV-2 variants of concern (VOC) carrying mutations reduce the effectiveness of nAbs by preventing neutralization....
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