Article

AKT-mediated phosphorylation of Sox9 induces Sox10 transcription in a murine model of HER2-positive breast cancer.

2020-08-04

Abstract excerpt

<h4>Background: </h4> Approximately 5-10% of HER2-positive breast cancers can be defined by low expression of the Ste20-like kinase, SLK, and high expression of SOX10. Our lab has observed that genetic deletion of SLK results in the induction of Sox10 and significantly accelerates tumor initiation in a HER2-induced mammary tumor model. However, the mechanism responsible for the induction of SOX10 gene expression i...

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Literature Corpus work: ce027a9d-5131-5468-b535-284b50cafdfa
DOI: 10.21203/rs.3.rs-50124/v1

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