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Article

IDH mutation impairs histone demethylation and results in a block to cell differentiation.

Nature - 15 Feb 2012

Lu Chao, Ward Patrick S, Kapoor Gurpreet S, Rohle Dan, Turcan Sevin, Abdel-Wahab Omar, Edwards Christopher R, Khanin Raya, Figueroa Maria E, Melnick Ari, Wellen Kathryn E, O'Rourke Donald M, Berger Shelley L, Chan Timothy A, Levine Ross L, Mellinghoff Ingo K, Thompson Craig B

Abstract excerpt

Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML) and chondrosarcomas, and share a novel enzymatic property of producing 2-hydroxyglutarate (2HG) from α-ketoglutarate. Here we report that 2HG-producing IDH mutants can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22343901
DOI: 10.1038/nature10860
PMCID: PMC3478770

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22343901-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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IDH mutation impairs histone demethylation and results in a block to cell differentiation.PMID 22343901Read ↗

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