Article

Tradeoffs in Modeling Context Dependency in Complex Trait Genetics

2023-06-23

Abstract excerpt

Genetic effects on complex traits may depend on context, such as age, sex, environmental exposures or social settings. However, it is often unclear if the extent of context dependency, or Gene-by-Environment interaction (GxE), merits more involved models than the additive model typically used to analyze data from genome-wide association studies (GWAS). Here, we suggest considering the utility of GxE models in GWAS...

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Literature Corpus work: cdea228b-ae7d-5948-b048-53bdec555e54
DOI: 10.1101/2023.06.21.545998

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