When does accounting for gene-environment interactions improve complex trait prediction? A case study with Drosophila lifespan.

Abstract excerpt

Gene-environment interactions (G×E) have been shown to explain a non-negligible proportion of variance for a plethora of complex traits in different species, including livestock, plants, and humans. While several studies have shown that including G×E can improve prediction accuracy in agricultural species, no increase in accuracy has been observed in human studies. In this work, we sought to investigate the...

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