Discovery and characterization of gene-by-environment and epistatic genetic effects in a vertebrate model.

doi:10.1016/j.xgen.2026.101164

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Article

Discovery and characterization of gene-by-environment and epistatic genetic effects in a vertebrate model.

Cell genomics - 13 May 2026

Welz Bettina, Pierotti Saul, Fitzgerald Tomas, Thumberger Thomas, Suzuki Risa, Watson Philip, Fuss Jana, Cordeiro da Trindade Tiago, Defranoux Fanny, Ferreira Marcio, Naruse Kiyoshi, Loosli Felix, Gierten Jakob, Wittbrodt Joachim, Birney Ewan

Abstract excerpt

Phenotypic variation arises from interactions between genetic and environmental factors, but disentangling these effects for complex traits remains challenging in observational cohorts like human biobanks. Model organisms with controlled genetic and environmental variation complement human studies in analyzing higher-order effects such as gene-by-environment (G×E) interactions, dominance, and epistasis. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41672067
DOI: 10.1016/j.xgen.2026.101164
PMCID: PMC13174225

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