Article

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication

2025-07-28

Abstract excerpt

<h4>Summary</h4> Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats remain asymptomatic. To investigate how host-specific protein-protein interactions (PPIs) influence infection, we generated comparative PPI maps for SARS-CoV-2 and its bat-origin relative RaTG13 using affinity purification-mass spectrometry (AP-MS) in human and Rhinolophus ferr...

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Literature Corpus work: cdd87a9f-3826-5fbb-82b2-9bf3ef294fbe
DOI: 10.1101/2025.07.26.666918

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